Immunomodulatory activity of red ginseng against influenza A virus infection.
Identifieur interne : 000F35 ( Main/Exploration ); précédent : 000F34; suivant : 000F36Immunomodulatory activity of red ginseng against influenza A virus infection.
Auteurs : Jong Seok Lee [États-Unis] ; Hye Suk Hwang [États-Unis] ; Eun-Ju Ko [États-Unis] ; Yu-Na Lee [États-Unis] ; Young-Man Kwon [États-Unis] ; Min-Chul Kim [États-Unis] ; Sang-Moo Kang [États-Unis]Source :
- Nutrients [ 2072-6643 ] ; 2014.
Descripteurs français
- KwdFr :
- Administration par voie orale, Animaux, Antiviraux (pharmacologie), Cellules épithéliales (), Cellules épithéliales (métabolisme), Espèces réactives de l'oxygène, Extraits de plantes (pharmacologie), Femelle, Humains, Immunomodulation, Infections à Orthomyxoviridae (traitement médicamenteux), Lignée cellulaire, Liquide de lavage bronchoalvéolaire (), Modèles animaux de maladie humaine, Panax (), Pneumopathie infectieuse (traitement médicamenteux), Pneumopathie infectieuse (virologie), Poumon (), Poumon (cytologie), Souris, Souris de lignée BALB C, Stress oxydatif (), Viabilité microbienne (), Virus de la grippe A ().
- MESH :
- cytologie : Poumon.
- métabolisme : Cellules épithéliales.
- pharmacologie : Antiviraux, Extraits de plantes.
- traitement médicamenteux : Infections à Orthomyxoviridae, Pneumopathie infectieuse.
- virologie : Pneumopathie infectieuse.
- Administration par voie orale, Animaux, Cellules épithéliales, Espèces réactives de l'oxygène, Femelle, Humains, Immunomodulation, Lignée cellulaire, Liquide de lavage bronchoalvéolaire, Modèles animaux de maladie humaine, Panax, Poumon, Souris, Souris de lignée BALB C, Stress oxydatif, Viabilité microbienne, Virus de la grippe A.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Antiviral Agents (pharmacology), Bronchoalveolar Lavage Fluid (chemistry), Cell Line, Disease Models, Animal, Epithelial Cells (drug effects), Epithelial Cells (metabolism), Female, Humans, Immunomodulation, Influenza A virus (drug effects), Lung (cytology), Lung (drug effects), Mice, Mice, Inbred BALB C, Microbial Viability (drug effects), Orthomyxoviridae Infections (drug therapy), Oxidative Stress (drug effects), Panax (chemistry), Plant Extracts (pharmacology), Pneumonia (drug therapy), Pneumonia (virology), Reactive Oxygen Species.
- MESH :
- chemical , pharmacology : Antiviral Agents, Plant Extracts.
- chemistry : Bronchoalveolar Lavage Fluid, Panax.
- cytology : Lung.
- drug effects : Epithelial Cells, Influenza A virus, Lung, Microbial Viability, Oxidative Stress.
- drug therapy : Orthomyxoviridae Infections, Pneumonia.
- metabolism : Epithelial Cells.
- virology : Pneumonia.
- Administration, Oral, Animals, Cell Line, Disease Models, Animal, Female, Humans, Immunomodulation, Mice, Mice, Inbred BALB C, Reactive Oxygen Species.
Abstract
Ginseng herbal medicine has been known to have beneficial effects on improving human health. We investigated whether red ginseng extract (RGE) has preventive effects on influenza A virus infection in vivo and in vitro. RGE was found to improve survival of human lung epithelial cells upon influenza virus infection. Also, RGE treatment reduced the expression of pro-inflammatory genes (IL-6, IL-8) probably in part through interference with the formation of reactive oxygen species by influenza A virus infection. Long-term oral administration of mice with RGE showed multiple immunomodulatory effects such as stimulating antiviral cytokine IFN-γ production after influenza A virus infection. In addition, RGE administration in mice inhibited the infiltration of inflammatory cells into the bronchial lumens. Therefore, RGE might have the potential beneficial effects on preventing influenza A virus infections via its multiple immunomodulatory functions.
DOI: 10.3390/nu6020517
PubMed: 24473234
Affiliations:
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for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. jongseoklee78@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Hwang, Hye Suk" sort="Hwang, Hye Suk" uniqKey="Hwang H" first="Hye Suk" last="Hwang">Hye Suk Hwang</name><affiliation wicri:level="2"><nlm:affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. hshwang33@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 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University, Atlanta, GA 30303, USA. mistybluerain7@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Kwon, Young Man" sort="Kwon, Young Man" uniqKey="Kwon Y" first="Young-Man" last="Kwon">Young-Man Kwon</name><affiliation wicri:level="2"><nlm:affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. ymankwon@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Kim, Min Chul" sort="Kim, Min Chul" uniqKey="Kim M" first="Min-Chul" last="Kim">Min-Chul Kim</name><affiliation wicri:level="2"><nlm:affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. mckim001@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name><affiliation wicri:level="2"><nlm:affiliation>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA. kangsm8@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Inflammatory, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">Nutrients</title><idno type="eISSN">2072-6643</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Bronchoalveolar Lavage Fluid (chemistry)</term><term>Cell Line</term><term>Disease Models, Animal</term><term>Epithelial Cells (drug effects)</term><term>Epithelial Cells (metabolism)</term><term>Female</term><term>Humans</term><term>Immunomodulation</term><term>Influenza A virus (drug effects)</term><term>Lung (cytology)</term><term>Lung (drug effects)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Microbial Viability (drug effects)</term><term>Orthomyxoviridae Infections (drug therapy)</term><term>Oxidative Stress (drug effects)</term><term>Panax (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Pneumonia (drug therapy)</term><term>Pneumonia (virology)</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Cellules épithéliales ()</term><term>Cellules épithéliales (métabolisme)</term><term>Espèces réactives de l'oxygène</term><term>Extraits de plantes (pharmacologie)</term><term>Femelle</term><term>Humains</term><term>Immunomodulation</term><term>Infections à Orthomyxoviridae (traitement médicamenteux)</term><term>Lignée cellulaire</term><term>Liquide de lavage bronchoalvéolaire ()</term><term>Modèles animaux de maladie humaine</term><term>Panax ()</term><term>Pneumopathie infectieuse (traitement médicamenteux)</term><term>Pneumopathie infectieuse (virologie)</term><term>Poumon ()</term><term>Poumon (cytologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Stress oxydatif ()</term><term>Viabilité microbienne ()</term><term>Virus de la grippe A ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Bronchoalveolar Lavage Fluid</term><term>Panax</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Epithelial Cells</term><term>Influenza A virus</term><term>Lung</term><term>Microbial Viability</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Orthomyxoviridae Infections</term><term>Pneumonia</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules épithéliales</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Pneumopathie infectieuse</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Pneumopathie infectieuse</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pneumonia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Cell Line</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Immunomodulation</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Cellules épithéliales</term><term>Espèces réactives de l'oxygène</term><term>Femelle</term><term>Humains</term><term>Immunomodulation</term><term>Lignée cellulaire</term><term>Liquide de lavage bronchoalvéolaire</term><term>Modèles animaux de maladie humaine</term><term>Panax</term><term>Poumon</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Stress oxydatif</term><term>Viabilité microbienne</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ginseng herbal medicine has been known to have beneficial effects on improving human health. We investigated whether red ginseng extract (RGE) has preventive effects on influenza A virus infection in vivo and in vitro. RGE was found to improve survival of human lung epithelial cells upon influenza virus infection. Also, RGE treatment reduced the expression of pro-inflammatory genes (IL-6, IL-8) probably in part through interference with the formation of reactive oxygen species by influenza A virus infection. Long-term oral administration of mice with RGE showed multiple immunomodulatory effects such as stimulating antiviral cytokine IFN-γ production after influenza A virus infection. In addition, RGE administration in mice inhibited the infiltration of inflammatory cells into the bronchial lumens. Therefore, RGE might have the potential beneficial effects on preventing influenza A virus infections via its multiple immunomodulatory functions. </div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Lee, Jong Seok" sort="Lee, Jong Seok" uniqKey="Lee J" first="Jong Seok" last="Lee">Jong Seok Lee</name></region><name sortKey="Hwang, Hye Suk" sort="Hwang, Hye Suk" uniqKey="Hwang H" first="Hye Suk" last="Hwang">Hye Suk Hwang</name><name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name><name sortKey="Kim, Min Chul" sort="Kim, Min Chul" uniqKey="Kim M" first="Min-Chul" last="Kim">Min-Chul Kim</name><name sortKey="Ko, Eun Ju" sort="Ko, Eun Ju" uniqKey="Ko E" first="Eun-Ju" last="Ko">Eun-Ju Ko</name><name sortKey="Kwon, Young Man" sort="Kwon, Young Man" uniqKey="Kwon Y" first="Young-Man" last="Kwon">Young-Man Kwon</name><name sortKey="Lee, Yu Na" sort="Lee, Yu Na" uniqKey="Lee Y" first="Yu-Na" last="Lee">Yu-Na Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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